Tramadol ER is an ER formulation

Tramadol ER is an ER formulation of cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride combined with ethyl cellulose, dibutyl sebacate, polyvinylpyrrolidone, sodium stearyl fumarate, colloidal silicon dioxide, and polyvinyl alcohol (Figure 2 ) (Ultram ER PI 2006). Tramadol ER was recently approved as a nonscheduled analgesic for the control of moderate to moderately severe pain in adults who require treatment over an extended time period (Ultram ER PI 2006).