Efficacy Tramadol

Effectiveness in clinical practice and clinical trials is the standard by which the true potential of a drug is determined. Tramadol IR has been widely prescribed as an unscheduled opioid in the US for the treatment of chronic pain for more than 10 years, and has demonstrated efficacy and safety in the treatment of moderate to moderately severe pain (ACR 2000 ; Ultram PI 2004 ; Mattia and Coluzzi 2005 ). Although tramadol has opioid analgesic effects, significant abuse has not been demonstrated after long-term therapy (ACR 2000 ; Cicero, Inciardi, Adams, et al 2005 ).