Buy Tramadol Online for Pain
Chronic, noncancer pain such as that associated with osteoarthritis of the hip and knee is typically managed according to American College of Rheumatology guidelines. Patients unresponsive to first-line treatment with acetaminophen receive nonsteroidal antiinflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors. However, many patients may have chronic pain that is refractory to these agents, or they may be at risk for the gastrointestinal, renal, and cardiovascular complications associated with their use. Tramadol, a mild opioid agonist and norepinephrine and serotonin reuptake inhibitor, is recommended by current guidelines for the treatment of moderate to moderately severe pain in patients who have not responded to previous oral therapy, or in patients who have contraindications to COX-2 inhibitors and nonselective NSAIDs. An extended-release (ER) formulation of tramadol was approved by the US Food and Drug Administration in September 2005. In contrast with immediate-release (IR) tramadol, this ER formulation allows once-daily dosing, providing around-the-clock analgesia. In clinical studies, tramadol ER has demonstrated a lower incidence of adverse events than that reported for IR tramadol. Unlike nonselective NSAIDs and COX-2 inhibitors, tramadol ER is not associated with gastrointestinal, renal, or cardiovascular complications. Although tramadol is an opioid agonist, significant abuse has not been demonstrated after long-term therapy. It is concluded that tramadol ER has an efficacy and safety profile that warrants its early use for the management of chronic pain, either alone or in conjunction with nonselective NSAIDs and COX-2 inhibitors.
Composition: one tablet tramadol 50mg contains: active ingredient is tramadol hydrochloride 50 mg;
Additional ingredients: croscarmellose sodium, colloidal silicon dioxide anhydrous, microcrystalline cellulose, povidone, magnesium stearate, purified water;
The composition of the shell: polyethyl-acrylate, macrogol 6000, hypromellose, talc, titanium dioxide, purified water.
Description of tramadol 50mg tablets film-coated, white, biconvex, round, without a fault line.
The ingestion of tramadol 50mg (Lannacher) absorbed from the gastrointestinal tract almost completely. Bioavailability of tramadol 50mg (Lannacher) is about 70%. Drug and its metabolites are excreted in the urine, half-life is 6 hours.
Tramadol 50mg (Lannacher) should be used with caution in patients with drug addiction, mental confusion, reducing the respiratory centre, cranial hypertension, traumatic brain injury, epileptic syndrome, “acute” stomach.
To apply caution in patients with severe renal or hepatic insufficiency.
During the treatment it is not allowed to drink alcohol.
Features of influence of the drug on the ability to drive vehicles or potentially dangerous machinery.
Not it is recommended to engage in activities requiring increased attention and high speed of psychomotor reactions (driving vehicles and machinery) because of the potential adverse reactions.
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